Refractory Depression: When Standard Treatments Aren’t Enough Refractory depression, also known as treatment-resistant depression, occurs when someone with major depressive disorder doesn’t respond adequately to at least two different antidepressant medications given at proper doses for sufficient duration. If you’re reading this, you’ve likely tried multiple treatments without finding relief – and you’re not alone.… Continue reading Refractory Depression: Complete Treatment Guide 2025 | Dr. Ronald Lee MD